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Chemistry: THE ABILITY OF ATTAPULGITE CLAY AS A PHYSICAL ANTIDOTE IN ADSORPTION OF SOME DRUGS FROM SOLUTION

 

THE ABILITY OF ATTAPULGITE CLAY AS A PHYSICAL ANTIDOTE IN ADSORPTION OF SOME DRUGS FROM SOLUTION

Sameer M. Jassim ,Hussein K.A. Hussein, and Saadoon A. Isa* Department of Chemistry and Biochemistry, Saddam College of Medicine, Saddam University , Baghdad , Iraq.

(*) To whom correspondence is to be made Received: 22/V2000 Accepted: 8/9/2001

ABSTRACT

Adsorption from solution of amtriptyline -HCl, chlorpromazine-HCI and chlordiazepoxide -HCl on attapulgite clay surface has been carried out at different conditions of temperature, PH and ionic strength. The objective of this work is to investigate the ability of attapulgite as a suitable antidote in the treatment of poisoning by these drugs if taken in quntities exceeding the usual recommended doses. Quantitative estimation of adsorption uptake has been performed by the use of UV spectrophotometric technique. In neutral medium at 37.5 C the quantity adsorbed of the above drugs on attapulgite followed the order:

amitriptyline - HCl > chlorpromazine - HCI > chlordiazepoxide - HCl . Interpretation of results was based on Freundlich and Langmuir adsorption isotherms. The normal thermodynamic parameters were also calculated .


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